The immunoglobulin superfamily of neuronal cell adhesion molecules: Lessons from animal models and correlation with human disease
Identifieur interne : 001D57 ( Main/Exploration ); précédent : 001D56; suivant : 001D58The immunoglobulin superfamily of neuronal cell adhesion molecules: Lessons from animal models and correlation with human disease
Auteurs : Markella Katidou [Grèce] ; Marina Vidaki [Grèce] ; Maura Strigini [Grèce] ; Domna Karagogeos [Grèce]Source :
- Biotechnology Journal [ 1860-6768 ] ; 2008-12.
English descriptors
- Teeft :
- Acoustic stimuli, Addiction vulnerability, Adducted thumbs, Adhesion, Animal model, Animal models, Ankyrin, Anxiety disorders, Autism, Autism spectrum disorder, Axon, Axon guidance, Axon outgrowth, Axonal, Biol, Biotechnol, Biotechnology, Biotechnology journal, Bipolar, Bipolar disorder, Caspr, Cell adhesion molecule, Cell adhesion molecules, Cell biol, Cerebellar, Cerebellum, Cerebrospinal fluid, Chl1, Chromosome, Contactin, Contactin subfamilies, Contactins, Corticospinal tract, Crete, Defect, Deletion, Dendrite, Disorder, Drosophila, Elegans, Fear conditioning, Fibronectin type, Functional recovery, Gene, Genet, Glial, Glial cells, Gmbh, Hippocampus, Homologue, Human disease, Human disorder, Hydrocephalus, Igcams, Immunoglobulin, Immunoglobulin superfamily, Isoforms, Juxtaparanodal, Juxtaparanodal regions, Karagogeos, Kgaa, Knockout, Knockout mice, L1cam, Mental retardation, Molecule, Motor coordination, Mouse, Mouse models, Multiple sclerosis, Mutant, Mutant mice, Mutation, Myelinated, Myelinated fibers, Myelination, Ncam, Ncam expression, Ncam function, Ncam protein, Nervous system, Neural, Neural cell adhesion molecule, Neural crest cells, Neural recognition molecule, Neurite, Neurite activity, Neurite outgrowth, Neurofascin, Neurogenesis, Neurological disorders, Neuron, Neuronal, Neuronal igcams, Neuronal migration, Neurosci, Node, Nrcam, Olfactory, Olfactory bulb, Oligodendrocyte, Oligodendrocyte maturation, Outgrowth, Paranodal, Pathway, Phenotype, Plasma membrane, Polymorphism, Potassium channels, Precursor, Prefrontal, Prefrontal cortex, Purkinje cells, Ranvier, Recent studies, Receptor, Schachner, Schizophrenia, Schwann cells, Sclerosis, Sodium channels, Soluble forms, Spinal, Spinal cord, Subfamily, Subgroup, Superfamily, Synaptic, Synaptic plasticity, Syndrome, Vassilika vouton, Verlag, Verlag gmbh, Weinheim, Weinheim biotechnol.
Abstract
Neuronal cell adhesion molecules of the immunoglobulin superfamily (IgCAMs) play a crucial role in the formation of neural circuits at different levels: cell migration, axonal and dendritic targeting as well as synapse formation. Furthermore, in perinatal and adult life, neuronal IgCAMs are required for the formation and maintenance of specialized axonal membrane domains, synaptic plasticity and neurogenesis. Mutations in the corresponding human genes have been correlated to several human neuronal disorders. Perturbing neuronal IgCAMs in animal models provides powerful means to understand the molecular and cellular basis of such human disorders. In this review, we concentrate on the NCAM, L1 and contactin subfamilies of neuronal IgCAMs summarizing recent functional studies from model systems and highlighting their links to disease pathogenesis.
Url:
DOI: 10.1002/biot.200800281
Affiliations:
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<term>Adducted thumbs</term>
<term>Adhesion</term>
<term>Animal model</term>
<term>Animal models</term>
<term>Ankyrin</term>
<term>Anxiety disorders</term>
<term>Autism</term>
<term>Autism spectrum disorder</term>
<term>Axon</term>
<term>Axon guidance</term>
<term>Axon outgrowth</term>
<term>Axonal</term>
<term>Biol</term>
<term>Biotechnol</term>
<term>Biotechnology</term>
<term>Biotechnology journal</term>
<term>Bipolar</term>
<term>Bipolar disorder</term>
<term>Caspr</term>
<term>Cell adhesion molecule</term>
<term>Cell adhesion molecules</term>
<term>Cell biol</term>
<term>Cerebellar</term>
<term>Cerebellum</term>
<term>Cerebrospinal fluid</term>
<term>Chl1</term>
<term>Chromosome</term>
<term>Contactin</term>
<term>Contactin subfamilies</term>
<term>Contactins</term>
<term>Corticospinal tract</term>
<term>Crete</term>
<term>Defect</term>
<term>Deletion</term>
<term>Dendrite</term>
<term>Disorder</term>
<term>Drosophila</term>
<term>Elegans</term>
<term>Fear conditioning</term>
<term>Fibronectin type</term>
<term>Functional recovery</term>
<term>Gene</term>
<term>Genet</term>
<term>Glial</term>
<term>Glial cells</term>
<term>Gmbh</term>
<term>Hippocampus</term>
<term>Homologue</term>
<term>Human disease</term>
<term>Human disorder</term>
<term>Hydrocephalus</term>
<term>Igcams</term>
<term>Immunoglobulin</term>
<term>Immunoglobulin superfamily</term>
<term>Isoforms</term>
<term>Juxtaparanodal</term>
<term>Juxtaparanodal regions</term>
<term>Karagogeos</term>
<term>Kgaa</term>
<term>Knockout</term>
<term>Knockout mice</term>
<term>L1cam</term>
<term>Mental retardation</term>
<term>Molecule</term>
<term>Motor coordination</term>
<term>Mouse</term>
<term>Mouse models</term>
<term>Multiple sclerosis</term>
<term>Mutant</term>
<term>Mutant mice</term>
<term>Mutation</term>
<term>Myelinated</term>
<term>Myelinated fibers</term>
<term>Myelination</term>
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<term>Ncam expression</term>
<term>Ncam function</term>
<term>Ncam protein</term>
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<term>Neural</term>
<term>Neural cell adhesion molecule</term>
<term>Neural crest cells</term>
<term>Neural recognition molecule</term>
<term>Neurite</term>
<term>Neurite activity</term>
<term>Neurite outgrowth</term>
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<term>Neurogenesis</term>
<term>Neurological disorders</term>
<term>Neuron</term>
<term>Neuronal</term>
<term>Neuronal igcams</term>
<term>Neuronal migration</term>
<term>Neurosci</term>
<term>Node</term>
<term>Nrcam</term>
<term>Olfactory</term>
<term>Olfactory bulb</term>
<term>Oligodendrocyte</term>
<term>Oligodendrocyte maturation</term>
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<term>Polymorphism</term>
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<term>Prefrontal</term>
<term>Prefrontal cortex</term>
<term>Purkinje cells</term>
<term>Ranvier</term>
<term>Recent studies</term>
<term>Receptor</term>
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<term>Schwann cells</term>
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<term>Spinal</term>
<term>Spinal cord</term>
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<term>Subgroup</term>
<term>Superfamily</term>
<term>Synaptic</term>
<term>Synaptic plasticity</term>
<term>Syndrome</term>
<term>Vassilika vouton</term>
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<front><div type="abstract" xml:lang="en">Neuronal cell adhesion molecules of the immunoglobulin superfamily (IgCAMs) play a crucial role in the formation of neural circuits at different levels: cell migration, axonal and dendritic targeting as well as synapse formation. Furthermore, in perinatal and adult life, neuronal IgCAMs are required for the formation and maintenance of specialized axonal membrane domains, synaptic plasticity and neurogenesis. Mutations in the corresponding human genes have been correlated to several human neuronal disorders. Perturbing neuronal IgCAMs in animal models provides powerful means to understand the molecular and cellular basis of such human disorders. In this review, we concentrate on the NCAM, L1 and contactin subfamilies of neuronal IgCAMs summarizing recent functional studies from model systems and highlighting their links to disease pathogenesis.</div>
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